Single-Molecule Bio

Our current efforts in single-molecule biophysics focus on the development and application of real-time tracking based on fluorescence modulation, and on the development of signal processing and parameter estimation methods for single molecule fluorescence.

  • Single-molecule diffusometry, tracking-FCS and tracking-FRET
  • Conformational dynamics of chromatin
  • DNA hairpin kinetics

We are actively collaborating with the groups of Aaron Straight (Biochemistry), Daniel Herschlag (Biochemistry) and Andrew Spakowitz (Chemical Engineering).